Process Development

Brochures, Flyers and Other Literature

CV Therapeutics and Dow: Building a Relationship

Success Story: Development Increases Yield in Alkaloid Synthesis (31 KB PDF)

Success Story: Process Development Saves Time and Money (75 KB PDF)

Success Story: Rapid Scale-up from One Liter Glassware to 4000 Gallon Scale (60 KB PDF)

Success Story: Reduced Delivery Time with Enzymatic Resolution (65 KB PDF)

Dowpharma Scientific Publications
Please find detailed a synopsis of the papers and publications on Process Development that scientists from Dowpharma^SM have published and contributed to since 1998. Due to copyright law we are unable to reproduce the papers online. As such we have quoted the publication reference.

The Synthesis of OSU 6162: Efficient, Large-Scale Implementation of a Suzuki Coupling
Lipton, M. F.; Mauragis, M. A.; Maloney, M. T.; Veley, M. F.; VanderBor, D. W.; Newby, J. J.; Appell, R. B.; Daugs, E. D. Org. Process Res. Dev. 2003, 7, 385.

Streamlining Process R&D Using Multidimensional Analytical Technology
McConnell, J. R.; Barton, K. P.; LaPack, M. A.; DesJardin, M. A. Org. Process Res. Dev. 2002, 6, 700.

Synthesis of 2,4-Di-1-pyrrolidinyl-9H-pyrimido[4,5-b]indoles, Including Antiasthma Clinical Candidate PNU-142731A
Bundy, G. L.; Banitt, L. S.; Dobrowolski, P. J.; Palmer, J. R.; Schwartz, T. M.; Zimmerman, D. C.; Lipton, M. F.; Mauragis, M. A.; Veley, M. F.; Appell, R. B.; Clouse, R. C.; Daugs, E. D. Org. Process Res. Dev. 2001, 5, 144.

New Synthesis of a Protected Ketonucleoside by a Non-Cryogenic Oxidation with TFAA/DMSO
Appell, R. B.; Duguid, R. J. Org. Process Res. Dev. 2000, 4, 172.

The Preparation and Isolation of Chloramphenicol Palmitate in Toluene
Daugs, E. D. Org. Process Res. Dev. 2000, 4, 301.

Chemical Development of MDL 103371: An N-Methyl-D-Aspartate-Type Glycine Receptor Antagonist for the Treatment of Stroke
Watson, T. J. N.; Horgan, S. W.; Shah, R. S.; Farr, R. A.; Schnettler, R. A.; Nevill, Jr., R.; Weiberth, F. J.; Huber, E. W.; Baron, B. M.; Webster, M. E.; Mishra, R. K.; Harrison, B. L.; Nyce, P. L.; Rand, C. L.; Goralski, C. T. Org. Process Res. Dev. 2000, 4, 477.

Thermally Stable, Photoactive Polymerizable Diazines. Application in Polymer Technology
Wolf, R. A.; Grosso, P. V.; Platt, A. E.; Staples, T. L.; White, J. E. J. Polym. Sci.: Part A: Polym. Chem. 1999, 37, 3203.

Process Development in the Synthesis of the ACE Intermediate MDL 28,726
Horgan, S. W.; Burkhouse, D. W.; Cregge, R. J.; Freund, D. W.; LeTourneau, M.; Margolin, A.; Webster, M. E.; Henton, D. R.; Barton, K. P.; Clouse, R. C.; DesJardin, M. A.; Donaldson, R. E.; Fetner, N. J.; Goralski, C. T.; Heinrich, G. P.; Hoops, J. F.; Keaten, R. T.; McConnell, J. R.; Nitz, M. A.; Stolz-Dunn, S. K. Org. Process Res. Dev. 1999, 3, 241

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